Destination mail server returned error 250

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date: Tue, 28 Mar 2006 13:05:02 -0800, group: microsoft.public.exchange2000.win2000 back

Destination mail server returned error 250

Please help me with that error "Destination mail server returned error 250" 
in a Exchange Server with Mcafee GroupShield.
Thanks

date: Tue, 28 Mar 2006 13:05:02 -0800 author: dguerrero